Product Description

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Generic Premarin is widely known as Premarin

Other alternative names for Generic Premarin (Conjugated estrogens): Generic, Conjugated estrogens, Premarin, Conjugated estrogens, Premarin, Premarin 28 pills, Generic Premarin 28 pills.

All of these are different brands of the same active substance – Conjugated estrogens

Premarin (Premarine)

This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.

Premarin stands for Pregnant Mares’ Urine (PREgnant MARes’ urINe); PMU for short (we spell it both ways, with an “e”, PREgnant MARes’ urINE which is the older name used in Canada, and without — which is the more popular recent spelling, and the one that is a U.S. registered trademark).

Premarin (including Prempro, Premphase, Prempac, and Premelle) is a drug made up of conjugated estrogens obtained from the urine of pregnant mares — put out in many forms (pills, creams, injections, patches, vaginal rings) and is used to reduce the symptoms of menopause in women or women who have had a hysterectomy. It is also prescribed to nearly eliminate the risk of osteoporosis (the brittling of bones) and reduce the chance of heart disease in women over 50.

As of November 2003, approximately nine million American women are still taking some form of Premarin (1 million women in the United States were still taking Prempro pills as of June 2003, down from the 3.4 million taking the drug before the negative Women’s Health Initiative study results became known). This is a reduction of 25% from the high figure of approximately 12 million women taking PMU based medications in 1999. See also HorseAid’s “Prognosis for Premarin”.

About a third of the approximately fifty-five million post menopausal women in the United States are on estrogen replacement therapy (ERT), or hormone replacement therapy (HRT), and of them, about 49% currently use PMU based products (down from a high of 79% in 1999) — while there are a number of estrogens excreted by the pregnant mare, estrone sulfate, equilin, and equilenin are the most significant.

It is the only human estrogen replacement drug that is derived from an animal (hormones beginning with the letter “e” are specific to equines, hormones beginning with the letter “h” are specific to humans).

The company that distributes and markets it world-wide, Ayerst Organics Ltd. (the world’s only producer of PMU) is a subsidiary of Wyeth Inc. (Wyeth Laboratories, Inc. traces its roots to Philadelphia, Pennsylvania, U.S.A., where, in 1860, John Wyeth and his brother Frank established a drugstore). Wyeth Inc. is the world’s eight largest drug maker (2003), falling from the seventh position it had held for many years.

Safety info

Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using PREMARIN. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).

Using estrogen-alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

You and your healthcare provider should talk regularly about whether you still need treatment.

PREMARIN should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Estrogens increase the risk of gallbladder disease. Discontinue estrogen if loss of vision, pancreatitis, or liver problems occur. If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

The most common (≥5%) side effects are abdominal pain, asthenia, pain, back pain, headache, flatulence, nausea, depression, insomnia, breast pain, endometrial hyperplasia, leucorrhea, vaginal hemorrhage, and vaginitis.

INDICATIONS

PREMARIN is used after menopause: to reduce moderate to severe hot flashes; to treat moderate to severe menopausal changes in and around the vagina; and to help reduce the chances of getting osteoporosis (thin, weak bones).

If you are using or are considering using PREMARIN only to treat vaginal symptoms, consider topical therapies first. If you are using or are considering using PREMARIN only to prevent osteoporosis due to menopause, talk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for you. PREMARIN should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.